Phylogeny-based Protein Function Prediction
SIFTER (Statistical Inference of Function Through Evolutionary Relationships) is a statistical approach to predicting protein function that uses a protein family's phylogenetic tree, as the natural structure for representing protein relationships.
- Currently SIFTER has predictions for proteins across species.
- For queries not in our current results, try "Predict by seqence" to find SIFTER predictions for the closest homologs.
- Engelhardt BE, Jordan MI, Srouji JR, Brenner SE. 2011. Genome-scale phylogenetic function annotation of large and diverse protein families.Genome Research 21:1969-1980. doi:10.1101/gr.104687.109